A Study on Hospital Information System at a Tertiary Teaching Hospital

The Global Hospital Information Systems market is forecast to grow at a Compound Annual Growth Rate of 10% from 2010-2017. Healthcare organizations globally recognize the importance of investing in information technologies. The HIS systems are large computerized data bases intended primarily for communication, store health and administrative information. It is evident that the use of HIS offers tremendous opportunities to reduce clinical errors, support health care professionals decision making, increases the efficienc

New Approach to Electromagnetic Rectification and Inversion

Electrical Engineerin

Information Technology Managers Role and Responsibility: - A Study at Select Hospitals

Information Technology (IT) is considered to be the most rapidly growing segment in the world ecosystem. IT development permeates every human activity. IT has radically changed the way medicine is practiced and now it is not confined to developed countries. Developing countries such as India has kept pace with the world in modern technology. With enormous IT investments it has become increasingly important to maintain and monitor IT resources. IT managers are responsible to carry out the core IT, allied activities and have to wear a lot of hats to perform their job efficiently. The present study is exploratory in nature and is undertaken to identify information technology managers’ roles & responsibility in a hospital, to understand intricacy of IT manager. The sampling method followed is purposive sampling. The data was collected by face to face interview and data was analyzed through Interpretative Phenomenological Analysis. The research finding articulates that the Information technology managers play imperative roles. The IT managers role and responsibilities vary depends on the size, structure, nature of the hospital and its technology adaptation. The core role and responsibility of IT manages include Managerial role, Operational role, Web master role, Consultant role, Training role, Team leader role

CFD Study of Liquid Sodium inside a Wavy Tube for Laminar Convectors: Effect of Reynolds Number, Wave Pitch, and Wave Amplitude

Metallic tubes have been widely used as primary heat transfer elements in laminar convectors for domestic and aerospace heating purpose. This paper uses CFD tool to investigate the heat output and pressure drop of liquid sodium flowing inside a circular tube having a wavy profile throughout its length. The wavy tube can be utilized in laminar liquid metal convectors as basic heat transfer element. The effect of Reynolds number (500≤Re≤2000) wave pitch (25 mm≤λ≤100 mm) and wave amplitude (2 mm≤a≤6 mm) on the heat output and pressure drop has been numerically studied. Based on the CFD results important controlling parameters have been identified and it is concluded that the heat output from the wavy tube is affected by the wave pitch and the wave amplitude while the pressure drop is mostly affected by the Reynolds number and wave amplitude

Foxm1 regulates neural progenitor fate during spinal cord regeneration

From Wiley via Jisc Publications RouterHistory: received 2020-05-20, rev-recd 2021-06-24, accepted 2021-07-01, pub-electronic 2021-08-24Article version: VoRPublication status: PublishedFunder: Wellcome Trust; Grant(s): 205894/Z/17/ZFunder: Biotechnology and Biological Sciences Research Council Research Training Support; Id: http://dx.doi.org/10.13039/501100000268; Grant(s): BB/M011208/1Funder: UKRI|Medical Research Council (MRC); Id: http://dx.doi.org/10.13039/501100000265; Grant(s): MR/M008908/1Funder: Wellcome Trust (ISSF fund)Abstract: Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some of the molecular and cellular mechanisms that globally regulate tail regeneration have been characterised, tissue‐specific response to injury remains poorly understood. Using a combination of bulk and single‐cell RNA sequencing on isolated spinal cords before and after amputation, we identify a number of genes specifically expressed in the spinal cord during regeneration. We show that Foxm1, a transcription factor known to promote proliferation, is essential for spinal cord regeneration. Surprisingly, Foxm1 does not control the cell cycle length of neural progenitors but regulates their fate after division. In foxm1−/− tadpoles, we observe a reduction in the number of neurons in the regenerating spinal cord, suggesting that neuronal differentiation is necessary for the regenerative process. Altogether, our data uncover a spinal cord‐specific response to injury and reveal a new role for neuronal differentiation during regeneration

HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation [preprint]

Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains with highly similar sequence recognition properties, yet they impart the identity of different animal body parts. To understand how HOX TFs control their specific transcriptional programs in vivo, we compared HOXA2 and HOXA3 binding profiles in the mouse embryo. HOXA2 and HOXA3 directly cooperate with TALE TFs and selectively target different subsets of a broad TALE chromatin platform. Binding of HOX and tissue-specific TFs convert low affinity TALE binding into high confidence, tissue-specific binding events, which bear the mark of active enhancers. We propose that HOX paralogs, alone and in combination with tissue-specific TFs, generate tissue-specific transcriptional outputs by modulating the activity of TALE TFs at selected enhancers

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cancer. This inhibitory activity is reflected by a reduction in MCAM gene expression and increased promoter methylation in tumour tissue compared to normal breast tissue. However, increased CD146/MCAM expression is associated with poor prognosis in breast cancer, a characteristic that is difficult to reconcile with inhibition of TEM by CD146 and its epigenetic silencing. Single cell transcriptome data revealed MCAM expression in multiple cell types, including the malignant cells, tumour vasculature and normal epithelium. MCAM expressing malignant cells were in the minority and expression was associated with epithelial to mesenchymal transition (EMT). Furthermore, gene expression signatures defining invasiveness and a stem cell-like phenotype were most strongly associated with mesenchymal-like tumour cells with low levels of MCAM mRNA, likely to represent a hybrid epithelial/mesenchymal (E/M) state. Our results show that high levels of MCAM gene expression are associated with poor prognosis in breast cancer because they reflect tumour vascularisation and high levels of EMT. We suggest that high levels of mesenchymal-like malignant cells reflect large populations of hybrid E/M cells and that low CD146 expression on these hybrid cells is permissive for TEM, aiding metastasis